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The background to this work was the clear evidence over many decades of tamoxifen and also raloxifene and others reducing the risk of breast cancer in women at an elevated risk of disease, though with unknown effects in respect of duration of benefit.

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possibly unexpectedly, the advantage is equal greater at 15 years notwithstanding discontinuation of treatment at 5 years, and it 100 80 60 40 20 0 percentageriskreduction 0 5 10 years tamoxifen.

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There is evidence of an increased incidence of thromboembolic events, including deep-vein thrombosis and pulmonary embolism, during tamoxifen therapy.

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