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In post-marketing experience, overdose with methotrexate has generally occurred with oral and intrathecal administration, although intravenous and intramuscular overdose have also been reported.

Nsaids decrease the tubular secretion of methotrexate, thereby increasing its concentration in the plasma.

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I ve been on methotrexate for over 20 years, first in oral form and now in injectible form.

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However higher doses of methotrexate can cause significant hair loss.

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if vomiting, diarrhea, or stomatitis occur, which may result in dehydration, methotrexate should be discontinued until recovery occurs.

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