There is some evidence that omeprazole and esomeprazole, two medications in the same class as rabeprazole, can disturb the conversion of an anticoagulant medication called clopidogrel to its active metabolite.
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when concomitant administration of a ppi is required, consider using another acid-reducing agent with minimal or no cyp2c19 inhibitory effect on the formation of clopidogrel active metabolite see warnings and precautions 5.
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the generic version of the drug is called clopidogrel , and is available immediately at what is expected to be priced at 30 -40 lower than plavix s price of 4-a-day retail price.
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patients received clopidogrel 300 mg loading dose, followed by 75 mg day, n 1,752 or placebo n 1,739 , both in combination with asa 150 to 325 mg as a loading dose, followed by 75 to 162 mg day , a fibrinolytic agent and, when appropriate, heparin.
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plavix clopidogrel is an antithrombotic agent or platelet inhibitor that discourages platelets.
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For people who had intolerance to clopidogrel and aspirin, treatment with modified-release dipyridamole alone had an icer of 314 per qaly gained in comparison with no preventive therapy.
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