Although the clinical significance of this observation has not been established, a lower dosage of the drug may be required to produce a therapeutic effect, and increases in dosage of the drug in question should be made cautiously and in small increments when probalan is being coadministrated.
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probalan produces an insignificant increase in free sulfonamide plasma concentrations, but a significant increase in total sulfonamide plasma levels.
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in patients on probalan who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.
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